Target Synonym: TP53INP1;SIP;TP53DINP1;TP53INP1A;TP53INP1B;Teap;p53DINP1
Storage: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Background: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunogen: A synthetic peptide of human p53 DINP1
Dilution: WB 1:500-1:2000
Calculated MW: 18kDa/27kDa
Observed MW: 32kDa
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