P7C3, CAS 301353-96-8

NAMPT activator

Product Type: Activator

CAS No.: 301353-96-8

MolecularFormula: C21H18Br2N2O

Molecular Weight: 474,2

Source: Synthetic

Purity: >98% (TLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (40 mg/ml)

Appearance: Off-white powder

PubChem CID: 2836187

Scientific Background: P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preservescognitive capacity (1). Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis (2). Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson's disease (3). Restores hippocampal neurogenesis in a mouse model of Down Syndrome (4). The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD (5). Active in vivo.

References: 1. AA Pieper et al. Cell 2010 142:392. T Tesla et al. Proc. Natl. Acad. Sci. USA 2012 109:170163. H De Jesus-Cortes et al. Proc. Natl. Acad. Sci. USA 2012 109:170104. SE Latchney et al. Neurosci. Lett. 2015 591:865. G Wang et al. Cell 2014 158:1324

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-571-5MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-571-5MG
• Package Unit: 5 mg
• Quantity Unit: STK