Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 6-(2,4-difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one
Purity: ≥98%
Formula Markup: C19H20F2N4O4
Formula Weight: 406.4
CAS Number: 449811-01-2
Notes: Pamapimod is a potent inhibitor of p38α MAP kinase (IC50 = 14 nM).{33190} It displays over 30-fold selectivity for p38α over p38β, has no activity against p38δ or p38γ, and has limited activity against a panel of 350 other kinases. Pamapimod blocks LPS-induced TNF-α production by monocytes and IL-1β generation in whole blood, and it inhibits spontaneous TNF-α release from synovial explants from patients with rheumatoid arthritis.{33191,33189} It is orally bioavailable and abrogates inflammation and bone loss in an animal model of arthritis and pain in a rat model of hyperalgesia.{33191} Pamapimod suppresses the expression of inflammation-associated genes in primary, IL-1β-stimulated human chondrocytes.{33192}
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