Product Description: Pancuronium dibromide, a bis-quaternary steroid, is a neuromuscular relaxant. Pancuronium dibromide inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors. Pancuronium dibromide also inhibits cardiac muscarinic receptors and has a sympathomimetic action[1][2][3].
Applications: Neuroscience-Neuromodulation
Formula: C35H60Br2N2O4
References: [1]A D Fryer, et al. Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch Pharmacol. 1987 Apr;335(4):367-71./[2]E Maestrone, et al. Extracellular pancuronium affects sodium current in chick embryo sensory neurons. Br J Pharmacol. 1994 Jan;111(1):283-7./[3]J R Docherty, et al. A comparison of the effects of pancuronium bromide and its monoquaternary analogue, ORG NC 45, on autonomic and somatic neurotransmission in the rat. Br J Pharmacol. 1980;71(1):225-33.
CAS Number: 15500-66-0
Molecular Weight: 732.67
Compound Purity: 98.0
Research Area: Neurological Disease
Solubility: DMSO : ≥ 100 mg/mL/H2O : 100 mg/mL (ultrasonic)
Target: nAChR
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