Target Synonym: SCA;ARTD;Poly[ADP-ribose] synthase;Poly ADP ribose polymerase;poly(ADP-ribose) polymerase;Poly [ADP-ribose] polymerase;NAD(+) ADP-ribosyltransferase;ADP-ribosyltransferase diphtheria toxin-like;pADPRT;ADPRT;ADPRT 1;ADPRT1;ARTD1;PARP;PARP-1;PPOL;pADPRT-1;PARP1;Cleaved PARP;ADP-ribosyltransferase diphtheria toxin-like 1;APOPAIN;NAD(+) ADP-ribosyltransferase 1;Poly [ADP-ribose] polymerase 1;Poly ADP ribose polymerase 1;poly(ADP-ribose) polymerase 1;Poly[ADP-ribose] synthase 1;SCA1;ADPRT;ADPRT 1;ADPRT1;ARTD1;pADPRT-1;PARP;PARP-1;poly(ADP-ribose) polymerase 1;PPOL
Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Immunogen: Recombinant Human PARP-1 / PARP protein
Buffer: 0.2 μm filtered solution in PBS
Dilution: WB 1:500-1:1000;IHC-P 1:100-1:500;IP 0.2-1 μL/mg of lysate
Calculated MW: 113 kDa
Observed MW: 113 kDa
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