PAZ-417, CAS 481629-87-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 1-[[4-(1,1-dimethylethyl)phenyl]methyl]-5-(3-methylphenyl)-a-oxo-1H-indole-3-acetic acid

Purity: ≥95%

Formula Markup: C28H27NO3

Formula Weight: 425.5

CAS Number: 481629-87-2

Notes: A PAI-1 inhibitor (IC50 = 655 nM); selective for PAI-1 over tPA and plasminogen, as well as a panel of 40 neurotransmitter, endocrine, and enzymatic targets, at 10 µM; enhances cleavage of monomeric and oligomeric Aβ42 in a cell-free assay at 5 µM; reduces plasma Aβ40 and brain Aβ40 and Aβ42 levels in the Tg2576 transgenic mouse model of Alzheimer’s disease at 20 mg/kg; reverses cognitive deficits in the same model at 30 and 100 mg/kg

• SKU: CAY42122-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42122-1
• Package Unit: 1 mg
• Quantity Unit: STK