PBA-1105 (TFA)

Product Description: PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 TFA selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 TFA increases the autophagic flux of Ub-conjugated aggregates[1].

Formula: C41H49F3N2O8

References: [1]Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13(1):904.

Molecular Weight: 754.83

Compound Purity: 99.58

Research Area: Cancer; Neurological Disease

Target: Autophagy;AUTOTACs

• SKU: MEXHY-161743A-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-161743A-5
• Package Unit: 5 mg
• Quantity Unit: STK