PBIT, CAS 2514-30-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one

Purity: ≥98%

Formula Markup: C14H11NOS

Formula Weight: 241.3

CAS Number: 2514-30-9

Notes: Jumonji AT-rich interactive domain 1 (JARID1) demethylases mediate the removal of methyl groups from trimethylated lysine 4 on histone 3 (H3K4me3). PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 µM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively).{27801} It does not significantly affect the activity of UTX and JMJD3 demethylases.{27801} It increases trimethylation of H3K4 in HeLa cells and blocks the proliferation of tumor cells expressing high levels of JARID1B.{27801}

• SKU: CAY16272-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16272-5
• Package Unit: 5 mg
• Quantity Unit: STK