PBT-1033, CAS 747408-78-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 5,7-dichloro-2-[(dimethylamino)methyl]-8-quinolinol

Purity: ≥98%

Formula Markup: C12H12Cl2N2O

Formula Weight: 271.14196

CAS Number: 747408-78-2

Notes: A zinc and copper ionophore; induces the uptake of zinc, copper, and iron in M17 neuroblastoma cells at 2-10 µM; inhibits GSK3α and GSK3β phosphorylation in a zinc- and copper-dependent manner; prevents the formation of extracellular protease-resistent Aβ-zinc aggregates; increases dendritic spine density in the hippocampus of 4-month- and 14-month-old female Tg2576 mice, which overexpress mutant APP, at 30 mg/kg per day for 11 days; reduces the latency to escape during acquisition and after 24 hours in APP/PS1 transgenic mice in a model of Alzheimer’s disease at 30 mg/kg

• SKU: CAY42425-250
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 42425-250
• Package Unit: 250 mg
• Quantity Unit: STK