PCI 34051, CAS 950762-95-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide

Purity: ≥95%

Formula Markup: C17H16N2O3

Formula Weight: 296.3

CAS Number: 950762-95-5

Notes: PCI 34051 is a potent histone deacetylase (HDAC) 8 inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 μM, respectively).{21341} PCI 34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 - 4 μM), but not in other hematopoietic or solid tumor lines.{21341} This compound has also been used to support a critical role for HDAC8 in the coordinated deacetylation of the core cohesion component SMC3 during mitosis.{21527}

• SKU: CAY10444-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10444-100
• Package Unit: 100 mg
• Quantity Unit: STK