PD 158780, CAS 171179-06-9

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N4-(3-bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine

Purity: ≥98%

Formula Markup: C14H12BrN5

Formula Weight: 330.2

CAS Number: 171179-06-9

Notes: PD 158780 is a pyridopyrimidine derivative that reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor tyrosine kinase superfamily: EGFR (IC50 = 8 µM), ErbB2 (IC50 = 49 nM), ErbB3, and ErbB4 (IC50 = 52 nM).{28641} It does not inhibit PDGF or FGF-mediated tyrosine phosphorylation.{28641} At 0.5 µM, PD 158780 has been shown to induce G1 cell cycle arrest in MCF10A breast cancer cells.{28642}

• SKU: CAY13329-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 13329-25
• Package Unit: 25 mg
• Quantity Unit: STK