Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-[2-[[4-(diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea
Purity: ≥95%
Formula Markup: C28H41N7O3
Formula Weight: 523.7
CAS Number: 219580-11-7
Notes: The fibroblast growth factor receptors (FGFRs) are cell surface receptors with intrinsic tyrosine kinase activity, which is necessary for receptor activation and signal propagation. PD 173074 is a potent and selective inhibitor of FGFR tyrosine kinase activity, blocking autophosphorylation of FGFR1 with an IC50 value of 21.5 nM.{17312} For comparison, it weakly inhibits PDGFR and c-Src (IC50 = 17.6 and 19.8 μM, respectively) and has no effect on EGFR, InsR, MEK, or PKC.{17312} PD 173074 also prevents signaling, at nanomolar levels, through FGFR2-5.{17313,17314,17315,17316,17317} Inhibition of FGFR signaling using PD 173074, impairs angiogenesis as well as self-renewal of stem cells via ERK1/2 activation.{17313,17316,17317,17318,17319}
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