PD 98059, CAS 167869-21-8

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Formula Markup: C16H13NO3

Formula Weight: 267.3

CAS Number: 167869-21-8

Notes: PD 98059 is a noncompetitive inhibitor of the MAPK pathway.{12847,10421} It prevents the activation of MEK by Raf or MEK kinase (a MAP3K) with an IC50 value of 2-7 µM but does not inhibit Raf-activated MAP2K1.{13126} It inhibits Raf activation of MAP2K2 with an IC50 value of 50 µM.{13126} PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC50 = 35 µM in HEK293 cells).{42109} It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).

• SKU: CAY10006726-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10006726-10
• Package Unit: 10 mg
• Quantity Unit: STK