PDD 00017273, CAS 1945950-21-9

Product Description: PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM[1][2].

Applications: Cancer-programmed cell death

Formula: C23H26N6O4S2

References: [1]James DI, et al. First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to AZD2281. ACS Chem Biol. 2016 Nov 18;11(11):3179-3190. Epub 2016 Oct 12./[2]Gravells P, et al. Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase. DNA Repair (Amst). 2017 Apr;52:81-91.

CAS Number: 1945950-21-9

Molecular Weight: 514.62

Compound Purity: 99.23

Research Area: Cancer

Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Poly(ADP-ribose) Glycohydrolase (PARG)

• SKU: MEXHY-108360-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-108360-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK