Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monomethanesulfonate, dihydrate
Purity: ≥98%
Formula Markup: C17H20FN3O3 / CH3SO3H [2H2O]
Formula Weight: 465.5
CAS Number: 149676-40-4
Notes: Pefloxacin is a broad-spectrum and synthetic fluoroquinolone antibiotic and a methylated derivative of norfloxacin (Item No. 25975).{47756,47757} It is active against Gram-negative and Gram-positive bacteria, including clinical isolates of E. coli, K. pneumoniae, S. aureus, and G. vaginalis (MIC90s = 0.12, 0.5, 0.5, and 32 mg/L, respectively).{47756,47757} Pefloxacin selectively inhibits E. coli topoisomerase I and DNA gyrase over calf thymus topoisomerase I (IC50s = 45, 4.5, and >140 μg/ml, respectively) in cell-free assays.{47758} In vivo, pefloxacin is active against systemic E. coli, K. pneumoniae, and P. aeruginosa infections in mice with 50% of efficacy maximum (P50) values of 6.5, 29.2, and 219 mg/kg, respectively.{47759}
English
Deutsch
