Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-(phenoxy-2,3,4,5,6-d5)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monopotassium salt
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C16H12D5N2O5S / K
Formula Weight: 393.51126
CAS Number: 2699607-22-0
Notes: Penicillin V-d5 is intended for use as an internal standard for the quantification of penicillin V (Item No. 23635) by GC- or LC-MS. Penicillin V is a β-lactam antibiotic that inhibits the growth of bacteria.{36398,36399,36400} In vitro, penicillin V inhibits the growth of clinical isolates of Streptococci (MICs = 0.004-0.008 mg/L) and C. difficile (MICs = 1 to >256 mg/L).{36398,36399} Penicillin V also inhibits growth of S. aureus in vitro (MIC = 0.016 mg/L) and in vivo in a thigh model of infection in mice.{36400} It inhibits the growth of S. pyogenes in mice following one or two dose therapy with curative dose (CD50) values of 0.207 and 0.031 mg, respectively.{36401} Penicillin V (100 mg/kg per day, p.o.) prevents experimental acute otitis media in rats when administered prior to infection by pneumococci.{36402} Formulations containing penicillin V have been used to treat bacterial infections of the skin, throat, ear, mouth, and respiratory tract.
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