PF-07104091, CAS 2460249-19-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: carbamic acid N-(1-methylethyl)-(1R,3S)-3-[5-[[[3-(methoxymethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl]amino]-1H-pyrazol-3-yl]cyclopentyl ester

Purity: ≥95%

Formula Markup: C19H28N6O4

Formula Weight: 404.5

CAS Number: 2460249-19-6

Notes: PF-07104091 is an inhibitor of cyclin-dependent kinase 2 (Cdk2; Ki = 1.16 nM).{49898} It is selective for Cdk2 over glycogen synthase kinase 3β (GSK3β; Ki = 537.81 nM). PF-07104091 decreases proliferation of TOV-21G and OVCAR-3 ovarian and HCT116 colorectal cancer cells (IC50s = 4.8, 0.59, and 0.88 µM, respectively).{49899} In vivo, PF-07104091 (50 mg/kg per day) reduces tumor volume and weight in an HCT116 mouse xenograft model.

• SKU: CAY41356-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41356-10
• Package Unit: 10 mg
• Quantity Unit: STK