Product Description: PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
Applications: COVID-19-immunoregulation
Formula: C29H31F3N6O3
References: [1]Xue CB, et al. Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist. ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918./[2]Wang W, Chen XK, Zhou L, et al. Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis. Acta Pharmacol Sin. Published online December 12, 2023.
CAS Number: 1341224-83-6
Molecular Weight: 568.59
Compound Purity: 99.79
Research Area: Inflammation/Immunology; Endocrinology
Solubility: DMSO : ≥ 34 mg/mL/Ethanol : 133.33 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Target: CCR
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