Product Description: PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC50 values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration[1].
Applications: COVID-19-anti-virus
Formula: C21H19N3O2
References: [1]Rajagopalan LE, et al. Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity. J Pharmacol Exp Ther. 2010 Jun;333(3):707-16.
CAS Number: 1256264-62-6
Molecular Weight: 345.39
Compound Purity: 99.60
Research Area: Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: PKA;PKC;ROCK;SGK