Product Description: PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase (CK1ε and CK1δ), with IC50s of 7.7 nM and 14 nM, respectively.
Applications: Cancer-Kinase/protease
Formula: C19H22Cl2FN5
References: [1]Badura L, et al. An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. J Pharmacol Exp Ther. 2007 Aug;322(2):730-8. Epub 2007 May 14./[2]Cheong JK, et al. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/? and Wnt/β-catenin independent inhibition of mitotic spindle formation. Oncogene. 2011 Jun 2;30(22):2558-69./[3]Kennaway DJ, et al. Acute inhibition of casein kinase 1δ/ε rapidly delays peripheral clock gene rhythms. Mol Cell Biochem. 2015 Jan;398(1-2):195-206.
CAS Number: 950912-80-8
Molecular Weight: 410.32
Compound Purity: 99.96
Research Area: Cancer
Solubility: DMSO : ≥ 32 mg/mL/H2O : 100 mg/mL (ultrasonic)
Target: Casein Kinase
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