PF-670462 (hydrochloride), CAS 950912-80-8

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine, dihydrochloride

Purity: ≥99%

Formula Markup: C19H20FN5 / 2HCl

Formula Weight: 410.3

CAS Number: 950912-80-8

Notes: The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines.{23082,23080} PF-670462 is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC50 = 7.7 and 14 nM, respectively).{23083} It less effectively inhibits a wide variety of related or common kinases.{23083} Through its effects on CK1, PF-670462 disrupts circadian rhythms in cells and animals.{23083,23081} It also blocks the locomotor response to amphetamines in mice.{23080}

• SKU: CAY14588-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 14588-50
• Package Unit: 50 mg
• Quantity Unit: STK