Product Description: PFI-1 is a selective BET (bromodomain-containing protein) inhibitor for BRD4 with IC50 of 0.22 μM in a cell-free assay.
Applications: Cancer-Kinase/protease
Formula: C16H17N3O4S
References: [1]Picaud S, et al. PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains. Cancer Res. 2013 May 21. [Epub ahead of print]/[2]Fish PV, et al. Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit. J Med Chem. 2012 Nov 26;55(22):9831-7./[3]Cheng Z, et al. Inhibition of BET bromodomain targets genetically diverse glioblastoma. Clin Cancer Res. 2013 Apr 1;19(7):1748-59./[4]Kate E Lines, et al. Epigenetic modifiers reduce proliferation of human neuroendocrine tumour cell lines. Endocrine Abstracts (2013) 31 P149
CAS Number: 1403764-72-6
Molecular Weight: 347.39
Compound Purity: 99.87
Research Area: Cancer
Solubility: DMSO : 33.33 mg/mL (ultrasonic)
Target: Apoptosis;Autophagy;Epigenetic Reader Domain
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