PFK158, CAS 1462249-75-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2E-quinolinyl]-2-propen-1-one

Purity: ≥95%

Formula Markup: C18H11F3N2O

Formula Weight: 328.3

CAS Number: 1462249-75-7

Notes: PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3).{37211} It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.{37212}

• SKU: CAY22987-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22987-25
• Package Unit: 25 mg
• Quantity Unit: STK