Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide
Purity: ≥95%
Formula Markup: C15H17N3O2
Formula Weight: 271.3145
CAS Number: 478149-53-0
Notes: An agonist of α7 nAChRs; selective for α7 nAChRs over α4β2-, α4β4-, α3β2-, or α3β4 subunit-containing nAChRs and 5-HT3 (EC50s = 0.03, >100, >50, >100, >100, and 11 µM, respectively, in calcium mobilization assays); prevents decreases in the number of retinal ganglion cells in a rat model of glaucoma when applied topically; improves sensorimotor deficits and brain edema in a mouse model of intracerebral hemorrhage; increases the time spent with the novel object in the novel object recognition test and reverses amphetamine-induced auditory gating deficits in rats at 1 mg/kg; reduces food intake and body weight in rats
English
Deutsch
