Phthalazinone pyrazole, CAS 880487-62-7

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1(2H)-phthalazinone

Purity: ≥98%

Formula Markup: C18H15N5O

Formula Weight: 317.4

CAS Number: 880487-62-7

Notes: Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis.{19817} Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors.{19818} Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM).{19005} It does not inhibit Aurora B kinase at doses up to 100 μM.{19005} Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively).{19005}

• SKU: CAY10735-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10735-10
• Package Unit: 10 mg
• Quantity Unit: STK