PHTPP, CAS 805239-56-9

Shelf life (days): 730.0

Formulation: A crystalline solid

Formal Name: 4-[2-phenyl-5,7-bis(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl]-phenol

Purity: ≥98%

Formula Markup: C20H11F6N3O

Formula Weight: 423.3

CAS Number: 805239-56-9

Notes: PHTPP is a pyrazolo[1,5-α]pyrimidine-based ligand that acts as a full antagonist of estrogen ERβ receptors with 36-fold selectivity over ERα.{28105} It exhibits no significant agonism on ERα or ERβ.{28105} This compound has been used to selectively target ERβ in the study of the opposing effects of hormone therapy on tumors expressing either ER subtype. At 100 pM, PHTPP has been found to enhance SKOV3 and OV2008 ovarian cancer cell growth in in vitro assays.{28106}

• SKU: CAY16025-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16025-25
• Package Unit: 25 mg
• Quantity Unit: STK