Product Description: PI-1840 is a potent and selective chymotrypsin-like (CT-L) inhibitor for with an IC50 value of 27 nM. PI-1840 inhibits cell proliferation and arrest cell cycle at G2/M phase. PI-1840 induces apoptosis and induces autophagy. PI-1840 induces the accumulation of proteasome substrates p27, Bax, and IκB-α[1][2].
Applications: Cancer-Kinase/protease
Formula: C22H26N4O3
References: [1]Kazi A, et, al. Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity. J Biol Chem. 2014 Apr 25;289(17):11906-11915./[2]Chen Y, et, al. Non covalent proteasome inhibitor PI 1840 induces apoptosis and autophagy in osteosarcoma cells. Oncol Rep. 2019 May;41(5):2803-2817.
CAS Number: 1401223-22-0
Molecular Weight: 394.47
Compound Purity: 98.78
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : < 0.1 mg/mL
Target: Apoptosis;Autophagy;Bcl-2 Family;Caspase;NF-κB;PARP;Proteasome
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