PI-3065, CAS 955977-50-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-[[4-(cyclopropylmethyl)-1-piperazinyl]methyl]-2-(5-fluoro-1H-indol-4-yl)-4-(4-morpholinyl)-thieno[3,2-d]pyrimidine

Purity: ≥98%

Formula Markup: C27H31FN6OS

Formula Weight: 506.6

CAS Number: 955977-50-1

Notes: PI-3065 is an inhibitor of PI3K p110δ (IC50 = 15 nM).{32997} It is greater than 100-fold selective for p110δ over p110ɑ, p110β, p110γ, DNA protein kinase (DNA-PK), and mTOR. PI-3065 (75 mg/kg) decreases tumor weight and inhibits metastasis in a 4T1 murine mammary carcinoma model. The information regarding the kinase IC50 values and xenograft model was drawn from a paper that has been retracted; however, the information specified in the retraction statement has not been included.{32997}

• SKU: CAY9002394-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 9002394-25
• Package Unit: 25 mg
• Quantity Unit: STK