Product Description: Picolinamide (2-Picolinamide) is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[1][3].
Applications: Metabolism-protein/nucleotide metabolism
Formula: C6H6N2O
References: [1]Campbell PI, et al. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989 Oct;251(1):188-92. /[2]Uchigata Y, et al. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982 Jun 10;257(11):6084-8. /[3]Yamamoto H, et al. Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. Biochem Biophys Res Commun. 1980 Jul 16;95(1):474-81. /[4]amagami T, et al. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 1985 Apr;45(4):1845-9.
CAS Number: 1452-77-3
Molecular Weight: 122.127
Compound Purity: 99.97
Research Area: Metabolic Disease
Solubility: DMSO : 50 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)
Target: PARP
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