PIK-90, CAS 677338-12-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(2,3-dihydro-7,8-dimethoxyimidazo[1,2-c]quinazolin-5-yl)-3-pyridinecarboxamide

Purity: ≥98%

Formula Markup: C18H17N5O3

Formula Weight: 351.4

CAS Number: 677338-12-4

Notes: PIK-90 is a potent and cell permeable phosphoinositide 3-kinase (PI3K) inhibitor (IC50 = 11, 350, 18, and 58 nM for p110 subunit isoforms α, β, γ, and δ, respectively).{21846} Through this action, PIK-90 reduces chemotaxis and induces apoptosis in chronic lymphocytic leukemia B cells.{21846} It also blocks proliferation of glioma cells in vitro.{14311} By inhibiting P110α, PIK-90 blocks insulin-stimulated phosphorylation of Akt in L1 adipocytes and L6 myotubes, preventing activation of the mTORC1 pathway.{14312}

• SKU: CAY10010749-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10010749-5
• Package Unit: 5 mg
• Quantity Unit: STK