Pinometostat, CAS 1380288-87-8

Product Description: Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor with a Ki of 80 pM.

Applications: Cancer-programmed cell death

Formula: C30H42N8O3

References: [1]Daigle SR, et al. Potent inhibition of DOT1L as treatment for MLL-fusion leukemia. Blood. 2013 Jun 25. [Epub ahead of print]/[2]Klaus CR, et al. DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells. J Pharmacol Exp Ther. 2014 Sep;350(3):646-56.

CAS Number: 1380288-87-8

Molecular Weight: 562.71

Compound Purity: 99.99

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)/Ethanol : 100 mg/mL (ultrasonic)

Target: Histone Methyltransferase

• SKU: MEXHY-15593-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-15593-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK