Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2,3,3a,4,5,6-hexahydro-2-d-8-methyl-1H-pyrazino[3,2,1-jk]carbazole-1,1,2-d3, monohydrochloride
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C15H14D4N2 / HCl
Formula Weight: 266.80178
CAS Number: 1801617-88-8
Notes: Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole (Item No. 22060) by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor (IC50s = 250 and 34.2 nM for rat brain and heart MAO-A, respectively).{38285} It is selective for MAO-A over MAO-B (Kis = 52,100 and 59,900 nM, for rat brain and heart MAO-B, respectively). In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons.{38286} Pirlindole is also an inhibitor of enterovirus-D68 and coxsackievirus B3 (CV-B3), inhibiting the genome replication phase of CV-B3 infection with an EC50 value of 7.7 µM independent of MAO-A activity.{38287}
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