Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 6S-((E)-2-(2-cyclopropyl-4-(4-fluorophenyl-2,3,5,6-d4)quinolin-3-yl)vinyl)-4R-hydroxytetrahydro-2H-pyran-2-one
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C25H18D4FNO3
Formula Weight: 407.5
Notes: Pitavastatin lactone-d4 is intended for use as an internal standard for the quantification of pitavastatin lactone (Item No. 21785) by GC- or LC-MS. Pitavastatin lactone is a major phase 2 metabolite of the HMG-CoA reductase inhibitor pitavastatin (Item No. 15414).{37247,25250} Pitavastatin lactone is formed when pitavastatin undergoes glucuronidation by the UDP-glucuronysyltransferase (UGT) isoforms UGT1A1, UGT1A3, or UGT2B7 to form pitavastatin glucuronide, which then undergoes non-enzymatic conversion to pitavastatin lactone. It can be retroconverted to pitavastatin via hydrolysis.
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