PK68, CAS 2173556-69-7

Product Description: PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC50 of ~90?nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis[1].

Applications: Cancer-Kinase/protease

Formula: C22H24N4O3S

References: [1]Jue Hou, et al. Discovery of potent necroptosis inhibitors targeting RIPK1 kinase activity for the treatment of inflammatory disorder and cancer metastasis. Cell Death Dis. 2019 Jun 24;10(7):493.

CAS Number: 2173556-69-7

Molecular Weight: 424.52

Compound Purity: 99.92

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 30 mg/mL (ultrasonic)

Target: RIP kinase

• SKU: MEXHY-128348-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-128348-10.1
• Package Unit: 10 mM/1 ml
• Quantity Unit: STK