Plinabulin, CAS 714272-27-2

Product Description: Plinabulin (NPI-2358) is a vascular disrupting agen (VDA) against tubulin-depolymerizing with an IC50 of 9.8 nM against HT-29 cells[1]. Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells[2].

Applications: Cancer-programmed cell death

Formula: C19H20N4O2

References: [1]Nicholson B et al. NPI-2358 is a tubulin-depolymerizing agent: in-vitro evidence for activity as a tumor vascular-disrupting agent. Anticancer Drugs. 2006 Jan;17(1):25-31./[2]Monica M. Mita et al. Phase 1 First-in-Human Trial of the Vascular Disrupting Agent Plinabulin (NPI-2358) in Patients with Solid Tumors or Lymphomas Clin Cancer Res. 2010 Dec 1;16(23):5892-9./[3]Bertelsen LB, et al. Vascular effects of plinabulin (NPI-2358) and the influence on tumour response when given alone or combined with radiation. Int J Radiat Biol. 2011 Nov;87(11):1126-34.

CAS Number: 714272-27-2

Molecular Weight: 336.39

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Microtubule/Tubulin

• SKU: MEXHY-14444-50
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-14444-50
• Package Unit: 50 mg
• Quantity Unit: STK