PNU 120596, CAS 501925-31-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(5-chloro-2,4-dimethoxyphenyl)-N’-(5-methyl-3-isoxazolyl)-urea

Purity: ≥98%

Formula Markup: C13H14ClN3O4

Formula Weight: 311.7

CAS Number: 501925-31-1

Notes: PNU 120596 is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor (nAChR), increasing agonist-evoked calcium flux (EC50 = 216 nM).{29718} It has no detectable effect on α4β2, α3β4, or α9β10 nAChRs. PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents in rat hippocampal slices and improves the auditory gating deficit caused by amphetamine in rats.{29718,29720} It also reduces the cortical/subcortical infarct volume caused by transient focal cerebral ischemia in rats.{29719}

• SKU: CAY14304-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 14304-25
• Package Unit: 25 mg
• Quantity Unit: STK