PNU 282987, CAS 711085-63-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-benzamide

Purity: ≥98%

Formula Markup: C14H17ClN2O

Formula Weight: 264.8

CAS Number: 711085-63-1

Notes: PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors (nAChRs; Ki = 26 nM for the rat receptor).{33473} It has negligible activity against α1β1γδ and α3β4 nAChRs as well as a panel of monoamine, muscarinic, glutamate, and GABA receptors, except 5-HT3 (Ki = 930 nM).{33473} PNU 282987 evokes whole-cell currents from cultured rat hippocampal neurons and enhances GABAergic synaptic activity when applied to hippocampal slices.{33474}

• SKU: CAY17424-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 17424-10
• Package Unit: 10 mg
• Quantity Unit: STK