Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (S)-N-((S)-4-amino-1-(((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methyloctanamide
Purity: ≥95%
Formula Markup: C56H98N16O13
Formula Weight: 1203.5
CAS Number: 4135-11-9
Notes: The polymyxins are cationic peptides originally isolated from B. polymyxa.{22080} They bind and kill Gram-negative bacteria.{22081} The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B1 is a form of polymyxin B which terminates with 6-methyloctanamide. Polymyxin B1 is comparable to other B polymyxins in its ability to kill P. aeruginosa, A. baumannii, and K. pneumoniae isolates.{22082} Its relative pharmacokinetics and nephrotoxicity have not been examined.
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