Pomalidomide-PEG1-C2-N3, CAS 2271036-44-1

Product Description: Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1]. Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Applications: Cancer-programmed cell death

Formula: C17H18N6O5

References: [1]Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.

CAS Number: 2271036-44-1

Molecular Weight: 386.36

Compound Purity: 99.91

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: E3 Ligase Ligand-Linker Conjugates

• SKU: MEXHY-125843-25
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-125843-25
• Package Unit: 25 mg
• Quantity Unit: STK