PP121, CAS 1092788-83-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Purity: ≥98%

Formula Markup: C17H17N7

Formula Weight: 319.4

CAS Number: 1092788-83-4

Notes: PP121 is a potent dual inhibitor of tyrosine and phosphoinositide kinases with IC50 values ranging from 2 to 60 nM for p110α, mTOR, Src, Abl, and VEGFR.{17883} It demonstrates >90% inhibition of tyrosine kinases and 50 = 50 nM) in vitro. It blocks VEGF-driven human umbilical vein endothelial cell (HUVEC) tube formation (IC50 = 0.31 nM), an in vitro model of tumor angiogenesis. PP121 also inhibits MEKK2/MAP3K2 (IC50 = 31 nM), a kinase important for tumor growth and metastasis.{38183}

• SKU: CAY21196-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 21196-5
• Package Unit: 5 mg
• Quantity Unit: STK