PQR530, CAS 1927857-61-1

Shelf life (days): 730.0

Formulation: A crystalline solid

Formal Name: 4-(difluoromethyl)-5-[4-[(3S)-3-methyl-4-morpholinyl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-pyridinamine

Purity: ≥98%

Formula Markup: C18H23F2N7O2

Formula Weight: 407.418006

CAS Number: 1927857-61-1

Notes: PQR530 is a dual inhibitor of PI3Kα and mammalian target of rapamycin (mTOR; IC50s = 11.1 and 7.4 nM, respectively).{50007} It inhibits phosphorylation of Akt and ribosomal S6 kinase in A2058 melanoma cells (IC50s = 62.2 and 61.1 nM, respectively). PQR530 inhibits cell growth in a panel of 66 cancer cell lines (mean GI50 = 0.43 µM). In vivo, PQR530 (25 mg/kg) reduces tumor growth in an OVCAR-3 ovarian cancer mouse xenograft model. It decreases the number of seizures per week in a Tsc1GFAP conditional knockout mouse model of epilepsy.{58361}

• SKU: CAY28563-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28563-25
• Package Unit: 25 mg
• Quantity Unit: STK