Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (2Z)-2-methyl-2-butenoic acid, (9S,10S)-10-(acetyloxy)-9,10-dihydro-8,8-dimethyl-2-oxo-2H,8H-benzo[1,2-b:3,4-b']dipyran-9-yl ester
Purity: ≥95%
Formula Markup: C21H22O7
Formula Weight: 386.39518
CAS Number: 73069-27-9
Notes: (+)-Praeruptorin A is a coumarin derivative originally isolated from P. praeruptorum.{36657} It prevents LPS-induced increases in IL-1β and TNF-α in a concentration-dependent manner when used at concentrations ranging from 6.25 to 100 µM and IL-6 at concentrations ranging from 25 to 100 µM.{36658} It inhibits potassium chloride-induced contraction of isolated rabbit trachea by 50 and 100% when used at concentrations of 4.8 and 30 µM, respectively.{36659} Topical administration of (+)-praeruptorin A (0.3 µmol/cm2) reduces edema by 22% in a croton oil mouse model of inflammation.{36660}
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