PRGL493, CAS 2479378-45-3

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(4-(3-(5-methylfuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)-3,4-dihydrobenzo[4,5]imidazo[1,2-a][1,3,5]triazin-2-yl)acetamide

Purity: ≥98%

Formula Markup: C25H21N7O2

Formula Weight: 451.48022

CAS Number: 2479378-45-3

Notes: PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).{54609} It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 µM. PRGL493 (5 µM) reduces production of progesterone (Item No. 15876) induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.

• SKU: CAY32748-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 32748-5
• Package Unit: 5 mg
• Quantity Unit: STK