Shelf life (days): 1460.0
Formulation: A solid
Formal Name: (2S)-7-[(ß-D-glucopyranosyloxy)methyl]-2,3-dihydro-2-(1-hydroxy-1-methylethyl)-4-methoxy-5H-furo[3,2-g][1]benzopyran-5-one
Purity: ≥98%
Formula Markup: C22H28O11
Formula Weight: 468.45112
CAS Number: 80681-45-4
Notes: Prim-O-glucosylcimifugin is a chromone that has been found in Cimicifuga dahurica and has diverse biological activities.{64142,64143,64144,64145} It inhibits the proliferation of EGF-stimulated MCF-7 breast cancer cells when used at a concentration of 10 µM.{64142} Prim-O-glucosylcimifugin (15, 50, and 100 µg/ml) reduces LPS-induced increases in the production of nitric oxide (NO), TNF-α, IL-6, and IL-1β in RAW 264.7 macrophages.{64143} It decreases pulmonary edema in a mouse model of LPS-induced acute lung injury when administered at doses ranging from 2.5 to 10 mg/kg.{64144} Prim-O-glucosylcimifugin inhibits formalin-induced tonic pain in rats (ED50 = 1.6 mg/animal).{64145}
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