Shelf life (days): 730.0
Formulation: A crystalline solid
Formal Name: 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone
Purity: ≥95%
Formula Markup: C17H11Br2NO2S2
Formula Weight: 485.2
CAS Number: 893449-38-2
Notes: Phosphatase of regenerating liver 3 (PRL-3; also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases.{30259,30260} It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay.{30259} PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin β1 and modulates VEGF-mediated endothelial cell migration.{30262,30264} It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines.{30261,30263}
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