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Protein Tag: N-His
Uniprot: Q9UM47
Accession: Q9UM47
Background: Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes . The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. In both vertebrates and invertebrates, Notch signaling is important for specifying cell fates and for defining boundaries between different cell types.
Bio Acitivity: Not validated for activity
Sequence: Val 1289-Cys 1458
Purity: > 95% as determined by reducing SDS-PAGE.
Formulation: Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Endotoxin: < 10 EU/mg of the protein as determined by the LAL method.
Calculated MW: 18.6 kDa
Observed MW: 20 kDa
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