Recombinant Mouse CCL12 Protein(Trx Tag)

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Protein Tag: N-Trx

Uniprot: Q62401

Accession: Q62401

Background: Ccl12 prevented initiation of the reparative response by prolonging inflammation and inhibiting fibroblast conversion to myofibroblasts, resulting in diminished scar formation. Macrophage secretion of Ccl12 directly impaired fibronectin and collagen deposition and indirectly stimulated collagen degradation through upregulation of matrix metalloproteinase-2. In post-MI patients, circulating LPS levels strongly associated with the Ccl12 homologue monocyte chemotactic protein 1 (MCP-1). Both MCP-1 and MCP-5 are HIF-1 target genes and that HIF-1alpha is involved in transcriptional induction of these two chemokines in astrocytes by hypoxia.

Bio Acitivity: Not validated for activity

Sequence: Gly23-Gly104

Purity: > 90% as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Endotoxin: < 10 EU/mg of the protein as determined by the LAL method

Calculated MW: 28.9 kDa

Observed MW: 32 kDa

• SKU: ELSPDEM100197-500
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: PDEM100197-500
• Package Unit: 500μg
• Quantity Unit: STK