Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2,3-dihydro-6-(propyl-2,2,3,3,3-d5)-2-thioxo-4(1H)-pyrimidinone
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C7H5D5N2OS
Formula Weight: 175.26348
CAS Number: 1189423-94-6
Notes: Propylthiouracil-d5 is intended for use as an internal standard for the quantification of propylthiouracil (Item No. 14069) by GC- or LC-MS. Propylthiouracil (PTU) is a thioamide antithyroid agent.{52763} It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3'-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds.{22286} Formulations containing propylthiouracil have been used in the treatment of Graves' disease and hyperthyroidism.
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