Prostaglandin D Synthase (hematopoietic-type) Inhibitor I, CAS 1033836-12-2

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 6-(3-fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-3-pyridinecarboxamide

Purity: ≥98%

Formula Markup: C19H19F4N3O

Formula Weight: 381.4

CAS Number: 1033836-12-2

Notes: Prostaglandin D synthase (hematopoietic-type) (H-PGDS) inhibitor I is an inhibitor of H-PGDS (IC50 = 32 nM for the human enzyme).{28198} It is selective for H-PGDS over lipocalin-type PGDS, microsomal prostaglandin E synthase-1 (mPGES-1), COX-1, COX-2, and 5-lipoxygenase (5-LO; IC50s = >10,000 nM for all). H-PGDS inhibitor I (1 or 10 mg/kg) inhibits PGD2 (Item No. 12010) production in vivo in rat spleen. It completely inhibits allergen-induced airway hyperresponsiveness in an ovine model of asthma.

• SKU: CAY16256-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 16256-1
• Package Unit: 1 mg
• Quantity Unit: STK