PSI-7977, CAS 1190307-88-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine, 1-methylethyl ester

Purity: ≥98%

Formula Markup: C22H29FN3O9P

Formula Weight: 529.5

CAS Number: 1190307-88-0

Notes: PSI-7977 is a prodrug form of the nucleoside analog and RNA-dependent RNA polymerase (RdRp) inhibitor PSI-7411.{25066} It is converted to PSI-7411 by cathepsin A and carboxylesterase 1 (CES1) via the intermediate PSI-352707. PSI-7977 inhibits hepatitis C virus (HCV) replication in an HCV replicon assay (EC50 = 0.092 µM). It also inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human brain cortical organoids derived from induced pluripotent stem cells (iPSCs) when used at a concentration of 20 µM.{62921} Formulations containing PSI-7977 have been used in the treatment of HCV infections.

• SKU: CAY15402-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 15402-5
• Package Unit: 5 mg
• Quantity Unit: STK